A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives

…, K McVety, AP Spada, A Zilberstein

Index: Maguire, Martin P.; Sheets, Kimberly R.; McVety, Karen; Spada, Alfred P.; Zilberstein, Asher Journal of Medicinal Chemistry, 1994 , vol. 37, # 14 p. 2129 - 2137

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Citation Number: 430

Abstract

A series of 63 3-substituted quinoline derivatives has been prepared and tested for inhibition of cell-free platelet derived growth factor receptor tyrosine kinase (PDGF-RTK) activity. The compounds were generally prepared either by a Friedlander condensation between an arylacetaldehyde and an o-aminobenzaldehyde or by a palladium-catalyzed coupling between an aryl bromide or triflate and an organostannane or organozinc chloride. The ...