Organic letters

Suzuki–Miyaura cross-coupling of heteroaryl halides and arylboronic acids in continuous flow

T Noël, AJ Musacchio

Index: Noel, Timothy; Musacchio, Andrew J. Organic Letters, 2011 , vol. 13, # 19 p. 5180 - 5183

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Citation Number: 46

Abstract

General continuous-flow conditions for the Suzuki–Miyaura cross-coupling of heteroaryl halides and (hetero) arylboronic acids have been developed. A wide range of heterobiaryl products is obtained in excellent yields (20 examples) employing low catalyst loadings (0.05– 1.5 mol% Pd).

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