The Journal of organic chemistry

Regioselective copper-catalyzed amination of chlorobenzoic acids: synthesis and solid-state structures of N-aryl anthranilic acid derivatives

X Mei, AT August, C Wolf

Index: Mei, Xuefeng; August, Adam T.; Wolf, Christian Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 142 - 149

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Citation Number: 47

Abstract

A chemo-and regioselective copper-catalyzed cross-coupling reaction for effective amination of 2-chlorobenzoic acids with aniline derivatives has been developed. The method eliminates the need for acid protection and produces a wide range of N-aryl anthranilic acid derivatives in up to 99% yield. The amination was found to proceed with both electron-rich and electron-deficient aryl chlorides and anilines and also utilizes ...