Intramolecular cyclization reaction-Palladium (0)-catalyzed cyclization is more effective than tin hydride mediated reaction

KC Majumdar, P Debnath, A Taher…

Index: Majumdar, Krishna C.; Debnath, Pradip; Taher, Abu; Pal, Amarta K. Canadian Journal of Chemistry, 2008 , vol. 86, # 4 p. 325 - 332

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Citation Number: 24

Abstract

Intramolecular CH arylation of pyrone, pyridone, uracil, imidazole, and benzimidazole derivatives are carried out in the presence of a Pd catalyst to form potentially bioactive fused heterocyclic compounds, whereas the n-Bu3SnH-mediated aryl radical cyclization of the precursors 3 afforded mainly halogen-reduced uncyclized products. Key words: Pd (0) catalyst, CH arylation, intramolecular cyclization, regioselectivity.

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