The gold-catalyzed Friedlander reaction was applied to the condensation of 2- aminoarylketones with β-keto-esters, β-diketones, β-keto-amides, and β-keto-sulfones to afford a diverse range of 2, 3, 4-trisubstituted quinolines in 3–82% yield. The seven- membered rings 1, 3-cycloheptadione and azepane-2, 4-dione reacted smoothly in 75% yield. An alternative procedure for the synthesis of 3-(methanesulfonyl) quinolines was ...
![1-[2-amino-5-(trifluoromethoxy)phenyl]-2-chloroethanone Structure](https://image.chemsrc.com/caspic/276/934829-56-8.png)
