Tetrahedron

Synthesis of 2, 2′-bipyrrole-5-carboxaldehydes and their application in the synthesis of B-ring functionalized prodiginines and tambjamines

P Kancharla, KA Reynolds

Index: Kancharla, Papireddy; Reynolds, Kevin A. Tetrahedron, 2013 , vol. 69, # 39 p. 8375 - 8385

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Citation Number: 8

Abstract

Abstract Facile, versatile, and cost-effective synthetic routes for the preparation of a range of new 3-alkyl-, 4-alkyl-, 3, 4-dialkyl-, and 3-halo-4-alkyl-2, 2′-bipyrrole-5-carboxaldehydes have been developed. These 2, 2′-bipyrrole-5-carboxaldehydes offer interesting potential as building blocks for making bioactive natural and unnatural products, as demonstrated by the synthesis of B-ring functionalized prodiginines (PGs) and tambjamines.