Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K

…, SW Cowan-Jacob, M Missbach

Index: Altmann, Eva; Cowan-Jacob, Sandra W.; Missbach, Martin Journal of Medicinal Chemistry, 2004 , vol. 47, # 24 p. 5833 - 5836

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Citation Number: 56

Abstract

Cysteine proteases have received increasing interest as targets for therapeutic intervention in different disease areas. This has led to considerable efforts aimed at the discovery, design, and optimization of novel cysteine protease inhibitors. 1-6 Cathepsin K is a lysosomal cysteine protease which is considered to be the key enzyme responsible for resorption of the bone matrix. Its ability to degrade type I collagen both within and outside the helical regions make it a unique ...