(1 R)-2-endo-Bromoacetyl-1, 7, 7-trimethylbicyclo [2.2. 1] heptan-2-ol (endo-2- bromoacetylisoborneol) 4 and its trimethylsilyl ether 3 are presented as efficient reagents for the asymmetric Darzens reaction. From the α, β-epoxy ketone adducts the chiral inductor camphor is removed, by treatment with ceric (IV) ammonium nitrate, to yield the corresponding epoxy acids which are isolated as their dicyclohexylammonium salts.
![benzyl ((R)-4-methyl-1-oxo-1-((1R,2R,4R)-1,7,7-trimethyl-2-((trimethylsilyl)oxy)bicyclo[2.2.1]heptan-2-yl)pentan-3-yl)carbamate Structure](https://image.chemsrc.com/caspic/292/271600-14-7.png)
![benzyl N-[1-((p-methylphenyl)sulfonyl)-2-methypropyl]carbamate Structure](https://image.chemsrc.com/caspic/387/147169-18-4.png)
![benzyl ((R)-1-(4-chlorophenyl)-3-oxo-3-((1R,2R,4R)-1,7,7-trimethyl-2-((trimethylsilyl)oxy)bicyclo[2.2.1]heptan-2-yl)propyl)carbamate Structure](https://image.chemsrc.com/caspic/123/271600-23-8.png)
