Abstract New monodisperse nonionic surfactant molecules, based on lysine with two fatty acid chains in the hydrophobic part and one or two polyoxyethylene methoxycapped chains (EO n− Me) in the hydrophilic headgroup, are synthesized as mimics of natural lecithins. Their surface-activity properties indicate that these compounds have surfactant behavior whose global hydrophobic contribution is comparable to that of one fatty chain.