New aryl/heteroaryl C N bond cross-coupling reactions via arylboronic acid/cupric acetate arylation

PYS Lam, CG Clark, S Saubern, J Adams, MP Winters…

Index: Lam, Patrick Y. S.; Clark, Charles G.; Saubern, Simon; Adams, Jessica; Winters, Michael P.; Chan, Dominic M. T.; Combs, Andrew Tetrahedron Letters, 1998 , vol. 39, # 19 p. 2941 - 2944

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Citation Number: 660

Abstract

A new aryl/heteroaryl C N bond cross-coupling reaction via the arylboronic acid/cupric acetate arylation of N H containing heteroarenes has been discovered. This new methodology is mild, proceeds at room temperature exposed to air, and works for many heteroarenes and arylboronic acids providing good yields of N-arylated heteroarenes.