Inhibition of Secreted Phospholipase A2. 4-Glycerol Derivatives of 4, 5-Dihydro-3-(4-tetradecyloxybenzyl)-1, 2, 4-4 H-oxadiazol-5-one with Broad Activities

…, C Redeuilh, A Lamouri, F Massicot…

Index: Dong, Chang-Zhi; Ahamada-Himidi, Azali; Plocki, Stephanie; Aoun, Darina; Touaibia, Mohamed; Meddad-Bel Habich, Nadia; Huet, Jack; Redeuilh, Catherine; Ombetta, Jean-Edouard; Godfroid, Jean-Jacques; Massicot, France; Heymans, Francoise Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1989 - 2007

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Citation Number: 10

Abstract

Secreted phospholipases A2 (sPLA2s) have been reported to play an important role in various inflammatory conditions and thus represent an attractive therapeutic target. Previous SAR studies from our laboratory have revealed certain important features of our recently discovered specific hGIIA sPLA2 inhibitors, and we report here the synthesis and biological activities of glycerol-containing derivatives of our lead compound III (Figure 1). Efficient ...