Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2, 3-dihydrothiazolo [2, 3-a] isoindol-5 (9bH)-ones and related compounds with anti-HIV-1 …

A Mertens, H Zilch, B Koenig, W Schaefer…

Index: Mertens, Alfred; Zilch, Harald; Koenig, Bernhard; Schaefer, Wolfgang; Poll, Thomas; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2526 - 2535

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Citation Number: 132

Abstract

Introduction The human immune deficiency virus 1 is the causative agent of the acquired immune deficiency syndrome (AIDS). 2 The epidemic spread of this disease is dramatically increased by recent estimates of the WHO. 3 So far, the only approved drugs for the therapy of HIV-1 infection are 3'-azidothymidine (AZT, Zid~ vudine)~ and recently 2', 3'- didesoxyinoeine (ddI, Didano~ ine)~ and 2', 3'-didesoxycytidine (ddC, Zalcitabine). 6 ...