1, 5-Di (hetero) arylated-pyridin-2 (1H)-one derivatives have been readily obtained in good yields starting from 2-fluoro-5-pyridylboronic acid. The sequence comprises three steps:(i) palladium-catalysed Suzuki-Miyaura reaction;(ii) base-catalysed hydrolysis;(iii) copper- catalysed C–N coupling. X-ray crystal structures are reported for selected pyridin-2 (1H)-one derivatives. These compounds are of interest as new scaffolds for drug discovery.
