Low Catalyst Loadings for Ligand??Free Copper (I)??Oxide??Catalyzed N??Arylation of Methanesulfonamide in Water

BYH Tan, YC Teo, AH Seow

Index: Tan, Bryan Yong-Hao; Teo, Yong-Chua; Seow, Ai-Hua European Journal of Organic Chemistry, 2014 , vol. 2014, # 7 p. 1541 - 1546

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Citation Number: 2

Abstract

Abstract A simple and practical protocol for the cross-coupling of methanesulfonamide and aryl iodides under ligand-free copper (I)-oxide-catalyzed conditions in water is reported. The method allows the preparation of a wide variety of synthetically useful N-arylated methanesulfonamides in good to excellent yields (up to 90%) under the optimized conditions.