5′-O-Alkylpyridoxamines: Lipophilic Analogues of Pyridoxamine Are Potent Scavengers of 1, 2-Dicarbonyls

V Amarnath, K Amarnath, J Avance…

Index: Zagol-Ikapitte, Irene; Amarnath, Venkataraman; Bala, Manju; Roberts II, L. Jackson; Oates, John A.; Boutaud, Olivier Chemical Research in Toxicology, 2010 , vol. 23, # 1 p. 240 - 250

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Abstract

Pyridoxamine (PM) is a prospective drug for the treatment of diabetic complications. In order to make zwitterionic PM more lipophilic and improve its tissue distribution, PM derivatives containing medium length alkyl groups on the hydroxymethyl side chain were prepared. The

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