Rh (I)-Catalyzed Direct Arylation of Azines

AM Berman, RG Bergman…

Index: Berman, Ashley M.; Bergman, Robert G.; Ellman, Jonathan A. Journal of Organic Chemistry, 2010 , vol. 75, # 22 p. 7863 - 7868

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Citation Number: 49

Abstract

The Rh (I)-catalyzed direct arylation of azines has been developed. Quinolines and 2- substituted pyridines couple with aryl bromides to efficiently afford ortho-arylated azine products using the commercially available and air-stable catalyst [RhCl (CO) 2] 2. Electron- deficient and electron-rich aromatic bromides couple in good yields, and hydroxyl, chloro, fluoro, trifluoromethyl, ether, and ketone functionalities are compatible with the reaction ...

~57%

~51%

~72%

~67%

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