… -catalyzed cross-coupling reactions of heterocyclic chlorides with arylmagnesium halides and of polyfunctionalized arylcopper reagents with aryl bromides, chlorides, …

…, MA Schade, MN Cheemala, S Wirth, SA Guevara…

Index: Korn, Tobias J.; Schade, Matthias A.; Cheemala, Murthy N.; Wirth, Stefan; Guevara, Simon A.; Cahiez, Gerard; Knochel, Paul Synthesis, 2006 , # 21 p. 3547 - 3574

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Citation Number: 38

Abstract

Abstract A range of aromatic organocopper or organomagnesium compounds undergo smooth cross-coupling reactions with aryl bromides, chlorides, fluorides and tosylates, leading to polyfunctionalized aromatics or heterocycles in the presence of cobalt salts (5-7.5 mol%) as catalysts. Very mild reaction conditions are needed and, in the case of cross- coupling with organocopper compounds, Bu 4 NI (1 equiv) and 4-fluorostyrene (20 mol%) ...