2-[(2-Aminobenzyl) sulfinyl]-1-(2-pyridyl)-1, 4, 5, 6-tetrahydrocyclopent [d] imidazoles as a novel class of gastric H+/K+-ATPase inhibitors

M Yamada, T Yura, M Morimoto, T Harada…

Index: Yamada; Yura; Morimoto; Harada; Honma; Kinoshita; Sugiura Journal of Medicinal Chemistry, 1996 , vol. 39, # 2 p. 596 - 604

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Citation Number: 33

Abstract

Substituted 2-sulfinylimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase. The 4, 5-unsubstituted imidazole series 6-11 and the 1, 4, 5, 6- tetrahydrocyclopent [d] imidazole series 12 were found to be potent inhibitors of the acid secretory enzyme H+/K+-ATPase. Structure-activity relationships indicate that the substitution of 2-pyridyl groups at the 1-position of the imidazole moiety combined with (2- ...