Potential sweetening agents of plant origin. 13. An intensely sweet dihydroflavonol derivative based on a natural product lead compound

…, JM Pezzuto, DD Soejarto, AD Kinghorn

Index: Nanayakkara, N. P. Dhammika; Hussain, Raouf A.; Pezzuto, John M.; Soejarto, D. Doel; Kinghorn, A. Douglas Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1250 - 1253

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Citation Number: 31

Abstract

The dihydroflavonol dihydroquercetin 3-acetate (1) was isolated as a sweet constituent of the young shoots of Tessaria dodoneifolia (Hook. & Am.) Cabrera (Compositae). Compound 1 and dihydroquercetin 3-acetate 4'-(methyl ether)(2), a novel sjnthetic analogue of this natural product lead compound, were rated by a taste panel as being 80 and 400 times sweeter than a 2% w/v sucrose solution, respectively. Synthetic dihydroquercetin 4'-( ...