Ascertaining the Suitability of Aryl Sulfonyl Fluorides for [18F] Radiochemistry Applications: A Systematic Investigation using Microfluidics

…, MP Roberts, TQ Pham, I Greguric

Index: Matesic, Lidia; Wyatt, Naomi A.; Fraser, Benjamin H.; Roberts, Maxine P.; Pham, Tien Q.; Greguric, Ivan Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11262 - 11270

Full Text: HTML

Citation Number: 12

Abstract

Optimization of [18F] radiolabeling conditions and subsequent stability analysis in mobile phase, PBS buffer, and rat serum of 12 aryl sulfonyl chloride precursors with various substituents (electron-withdrawing groups, electron-donating groups, increased steric bulk, heterocyclic) were performed using an Advion NanoTek Microfluidic Synthesis System. A comparison of radiochemical yields and reaction times for a microfluidics device versus a ...