Modular Assembly of Macrocyclic Organo–Peptide Hybrids Using Synthetic and Genetically Encoded Precursors

JM Smith, F Vitali, SA Archer…

Index: Smith, Jessica M.; Vitali, Francesca; Archer, Steven A.; Fasan, Rudi Angewandte Chemie - International Edition, 2011 , vol. 50, # 22 p. 5075 - 5080

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Citation Number: 41

Abstract

Macrocyclic peptides and peptide-containing molecules are attractive molecular scaffolds for the development of bioactive compounds to modulate biomolecular interactions. These structures combine a high degree of functional complexity with restricted conformational flexibility, which make them well-suited to achieve selective and tight binding to extended biomolecular interfaces, such as those mediating protein–protein and protein–nucleic acid ...