Triphenylphosphine dibromide: effective and selective reagent for the cleavage of acetals

A Wagner, MP Heitz, C Mioskowski

Index: Wagner, Alain; Heitz, Marie-Paule; Mioskowski, Charles Journal of the Chemical Society, Chemical Communications, 1989 , # 21 p. 1619 - 1620

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Abstract

Triphenylphosphine dibromide (PPh3Br2) is a mild and highly effective reagent for hydrolysis of various acetals in dichloromethane at low temperature. ... Cleavage of the acetal function is required frequently in the synthesis of polyfunctional natural products. The most com- ... Scheme 1. Reagents and conditions: PPh3Brz, CH2C12, -50 "C, 92%. ... Published on 01 January 1989. Downloaded by google on 22/02/2016 20:24:45. ... View Article Online / Journal ...