Chemical Communications

Evolution of chiral Lewis basic N-formamide as highly effective organocatalyst for asymmetric reduction of both ketones and ketimines with an unprecedented …

L Zhou, Z Wang, S Wei, J Sun

Index: Zhou, Li; Wang, Zhouyu; Wei, Siyu; Sun, Jian Chemical Communications, 2007 , # 28 p. 2977 - 2979

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Citation Number: 42

Abstract

Catalyst 4 was previously observed to be slightly more enantioselective than its diastereomer 5a in the reduction of ketimines . 9c In contrast, in the reduction of ketone 6a, the latter was found to be more enantioselective (entry 4 vs. 3). Thus our attention was next directed to fine-tuning the structure of 5a in hope of achieving high efficiency and enantioselectivity for the reduction of ketones . ... Analogous catalysts 5b–h bearing different R groups were easily ...