Gram-scale synthesis of uridine 5'-diphospho-N-acetylglucosamine: comparison of enzymic and chemical routes

…, WJ Lees, P Pale, GM Whitesides

Index: Heidlas, Juergen E.; Lees, Watson J.; Pale, Patrick; Whitesides, George M. Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 146 - 151

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Citation Number: 69

Abstract

Practical chemoenzymatic and chemical routes to uridine 5'-diphoepho-N- acetylglucosamine (UDP-GlcNAc) on a gram scale have been developed. The chemoenzymatic synthesis provided convenient access to glucosamine&phosphate and N- acety~ lucoSamine-6-phosphate (GlcNAc-6-P) in> lO-mmol quantities. The condensation between GlcNAc-6-P and UTP was catalyzed by readily available crude enzyme extracts ...