The discovery of new potent non-peptide angiotensin II AT1 receptor blockers: A concise synthesis, molecular docking studies and biological evaluation of N- …

…, G Liapakis, T Mavromoustakos, J Matsoukas

Index: Agelis, George; Resvani, Amalia; Matsoukas, John; Durdagi, Serdar; Spyridaki, Katerina; Liapakis, George; Tumova, Tereza; Slaninova, Jirina; Giannopoulos, Panagiotis; Mavromoustakos, Thomas; Vlahakos, Demetrios European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 358 - 374,17 Title/Abstract Full Text Show Details Agelis, George; Resvani, Amalia; Durdagi, Serdar; Spyridaki, Katerina; Tumova, Tereza; Slaninova, Jirina; Giannopoulos, Panagiotis; Vlahakos, Demetrios; Liapakis, George; Mavromoustakos, Thomas; Matsoukas, John European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 358 - 374

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Citation Number: 12

Abstract

A convenient and facile synthesis, in silico docking studies and in vitro biological evaluation of N-substituted 5-butylimidazole derivatives as potent Angiotensin II (ANG II) receptor type 1 (AT1) blockers (ARBs) has been reported in the current study. Our efforts have been directed towards the development of an efficient synthetic route allowing the facile introduction of substituents on the imidazole ring. In particular, a series of imidazole based compounds ...