Potent, orally active imidazo [4, 5-b] pyridine-based angiotensin II receptor antagonists

NB Mantlo, PK Chakravarty, DL Ondeyka…

Index: Mantlo, Nathan B.; Chakravarty, Prasun K.; Ondeyka, Debra L.; Siegl, Peter K. S.; Chang, Raymond S.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2919 - 2922

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Citation Number: 175

Abstract

Angiotensin I1 is the principle pressor agent of the renin-angiotensin system (RAS). This system, a proteolytic cascade that regulates hemodynamics and water and electrolyte balance, can contribute to hypertensive states in man. The effecta of the octapeptide angiotensin I1 (AII), which include vasoconstriction, stimulation of aldosterone synthesis and release, cardiac stimulation, and renal reabsorption of sodium, are mediated through ...