Efficient and selective Pt/C-catalyzed HD exchange reaction of aromatic rings

…, H Esaki, T Maesawa, E Imamiya, T Maegawa…

Index: Ito, Nobuhiro; Esaki, Hiroyoshi; Maesawa, Tsuneaki; Imamiya, Eikoh; Maegawa, Tomohiro; Sajiki, Hironao Bulletin of the Chemical Society of Japan, 2008 , vol. 81, # 2 p. 278 - 286

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Citation Number: 38

Abstract

An effective and applicable deuteration method for aromatic rings using Pt/C–D 2 O–H 2 system was established. Especially, phenol was fully deuterated even at room temperature, and other electron-rich aromatic nuclei were efficiently deuterated under mild conditions. The scope and limitations of the presence method and its application to the synthesis of deuterium-labeled biologically active compounds and deuterium-labeled building blocks ...