Tetrahedron letters

Regioselective and high-yielding bromination of aromatic compounds using hexamethylenetetramine–bromine

MM Heravi, N Abdolhosseini, HA Oskooie

Index: Heravi, Majid M.; Abdolhosseini, Nafiseh; Oskooie, Hossein A. Tetrahedron Letters, 2005 , vol. 46, # 51 p. 8959 - 8963

Full Text: HTML

Citation Number: 53

Abstract

A regioselective and highly efficient method for bromination of aromatic compounds in the presence of a stoichiometric amount of hexamethylenetetramine–bromine (HMTAB) as an efficient reagent in dichloromethane is reported. The selectivity depends on the temperature and nature of the substituent on the substrate. The reactivity of this reagent was increased by supporting it to silica gel for bromination of less activated compounds.