Organic letters

Pd-Catalyzed Intramolecular Aerobic Oxidative C–H Amination of 2-Aryl-3-(arylamino) quinazolinones: Synthesis of Fluorescent Indazolo [3, 2-b] quinazolinones

W Yang, J Chen, X Huang, J Ding, M Liu, H Wu

Index: Shen, Yan; Chen, Jiuxi; Liu, Miaochang; Ding, Jinchang; Gao, Wenxia; Huang, Xiaobo; Wu, Huayue Chemical Communications, 2014 , vol. 50, # 33 p. 4292 - 4295

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Citation Number: 21

Abstract

A palladium-catalyzed intramolecular aerobic oxidative C–H amination of 2-aryl-3- (arylamino) quinazolinones has been developed, providing a variety of substituted indazolo [3, 2-b] quinazolinone derivatives in moderate to excellent yields. Preliminary mechanistic studies suggested that a palladacycle dimer could be the key intermediate, which underwent a cascade “rollover” cyclometalation and C–H amination sequence. Furthermore, the ...