Tetrahedron letters

New polystyrene-supported stable source of 2-pyridylboron reagent for Suzuki couplings in combinatorial chemistry

P Gros, A Doudouh, Y Fort

Index: Gros, Philippe; Doudouh, Abdelatif; Fort, Yves Tetrahedron Letters, 2004 , vol. 45, # 33 p. 6239 - 6241

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Citation Number: 47

Abstract

The Suzuki–Miyaura reaction is one of the most popular process for preparation of unsymmetrical biaryl compounds. 1 This Pd(0)-catalyzed coupling can be run under mild conditions with tolerance of a wide range of functionalities and weak sensitivity to steric effects. However, the literature essentially reports couplings between aryl boronic acids or esters and (het)aryl halides but only scarce examples of use of hetarylboronic derivatives. This is particularly obvious in ...