The Journal of organic chemistry

Pd (PPh3) 4-PEG 400 catalyzed protocol for the atom-efficient Stille cross-coupling reaction of organotin with aryl bromides

WJ Zhou, KH Wang, JX Wang

Index: Zhou, Wen-Jun; Wang, Ke-Hu; Wang, Jin-Xian Journal of Organic Chemistry, 2009 , vol. 74, # 15 p. 5599 - 5602

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Citation Number: 54

Abstract

Aryl bromides (4 equiv) were coupled efficiently with organotin (1 equiv) in an atom-efficient way using the tetra (triphenylphosphine) palladium/polyethylene glycol 400 (Pd (PPh3) 4/PEG 400) catalytic system in the presence of sodium acetate (NaOAc) as base at 100° C, providing excellent yields of the corresponding functionalized biaryls in short reaction times.