Iron??Catalyzed Chemoselective ortho Arylation of Aryl Imines by Directed C H Bond Activation

…, A Matsumoto, J Norinder, E Nakamura

Index: Yoshikai, Naohiko; Matsumoto, Arimasa; Norinder, Jakob; Nakamura, Eiichi Angewandte Chemie, International Edition, 2009 , vol. 48, # 16 p. 2925 - 2928

Full Text: HTML

Citation Number: 178

Abstract

Abstract No Fe-ar: Iron catalyzes an imine-directed C [BOND] H bond activation to introduce an ortho-aryl group to an acetophenone-derived imine using a diarylzinc reagent (see scheme), whereas palladium catalyzes the conventional substitution reaction. The title reaction features mild and selective C [BOND] H bond activation in the presence of aryl bromide, chloride, or sulfonate groups, and 1, 2-dichloroisobutane is essential to achieve ...