Tetrahedron

Improved synthesis of three brominated analogues of the potent environmental mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone (MX)

M Lloveras, I Ramos, E Molins, A Messeguer

Index: Lloveras, Maia; Ramos, Isabel; Molins, Elies; Messeguer, Angel Tetrahedron, 2000 , vol. 56, # 21 p. 3391 - 3397

Full Text: HTML

Citation Number: 9

Abstract

The synthesis of three brominated analogues of the environmental mutagen 3-chloro-4- (dichloromethyl)-5-hydroxy-2 (5H)-furanone (MX), namely, 3-chloro-4-(bromochloromethyl)- 5-hydroxy-2 (5H)-furanone (BMX-1), 3-chloro-4-(dibromomethyl)-5-hydroxy-2 (5H)-furanone (BMX-2) and 3-bromo-4-(dibromomethyl)-5-hydroxy-2 (5H)-furanone (BMX-3), by employing a simple procedure from a common precursor, is described.