Dialyzable Carbosilane Dendrimers as Soluble Supports for the Functionalization of Pyridine Fragments via Palladium-Catalyzed Coupling Reactions

J Le Nôtre, JJ Firet, LAJM Sliedregt, BJ van Steen…

Index: Le Notre, Jerome; Firet, Judith J.; Sliedregt, Leo A. J. M.; Van Steen, Bart J.; Van Koten, Gerard; Gebbink, Robertus J. M. Klein Organic Letters, 2005 , vol. 7, # 3 p. 363 - 366

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Citation Number: 27

Abstract

The use of carbosilane (CS) dendrimers as soluble supports in liquid phase organic synthesis (LPOS) is described. Control of the three key steps is perfectly achieved by covalently binding a pyridine fragment to the soluble support, modifying it via coupling reactions, and releasing it at the end. Nanofiltration (dialysis) allows facile purification of the supported molecules after each step.