e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Journal of medicinal chemistry

Antileukemic activity of substituted ureidothiazoles, ureidothiadiazoles, and related compounds

RKY Zee-Cheng, CC Cheng

Index: Zee-Cheng,K.Y.; Cheng,C.C. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 28 - 32

Full Text: HTML

Citation Number: 21

Abstract

1 carcinoma,'rhahdom?-osarcoma." other experimental systems.'and man." This drug acts as a nonspecific stimulant of the immune system." Levamisole and its analogues are inhibitors of alkaline phosphatase. 6 X fused benzimidazolylthiaz~) leacetic acid derivative 2 and a py- rimidylthiazoleacetic acid derivative 3 were also known to he artive against Lewis lung tumor.'Recently, a ureidothiazole derivative 4 (Carl~ olahs, 1nc. I

2-Aminothiazole Structure

2-Aminothiazole

ethyl 4-isocyanatobenzoate Structure

ethyl 4-isocyan...

~%

ethyl 4-(1,3-thiazol-2-ylcarbamoylamino)benzoate Structure

ethyl 4-(1,3-th...

ethyl 4-(1,3-thiazol-2-ylcarbamoylamino)benzoate Structure

ethyl 4-(1,3-th...

~%

4-(1,3-thiazol-2-ylcarbamoylamino)benzoic acid Structure

4-(1,3-thiazol-...

ethyl 4-isocyanatobenzoate Structure

ethyl 4-isocyan...

~%

4-(1,3-thiazol-2-ylcarbamoylamino)benzoic acid Structure

4-(1,3-thiazol-...

2-Amino-1,3,4-thiadiazole Structure

2-Amino-1,3,4-t...

4-nitrophenyl isocyanate Structure

4-nitrophenyl i...

~%

Urea, N-(4-nitrophenyl)-N-1,3,4-thiadiazol-2-yl- Structure

Urea, N-(4-nitr...

2-Amino-1,3,4-thiadiazole Structure

2-Amino-1,3,4-t...

ethyl 4-isocyanatobenzoate Structure

ethyl 4-isocyan...

~%

Benzoic acid,4-[[(1,3,4-thiadiazol-2-ylamino)carbonyl]amino]-, ethyl ester Structure

Benzoic acid,4-...

2-Amino-6-methoxybenzothiazole Structure

2-Amino-6-metho...

ethyl 4-isocyanatobenzoate Structure

ethyl 4-isocyan...

~%

Benzoicacid, 4-[[[(6-methoxy-2-benzothiazolyl)amino]carbonyl]amino]-, ethyl ester Structure

Benzoicacid, 4-...

2-Aminothiazole Structure

2-Aminothiazole

Benzoic acid,4-isothiocyanato-, ethyl ester Structure

Benzoic acid,4-...

~%

ethyl 4-(1,3-thiazol-2-ylthiocarbamoylamino)benzoate Structure

ethyl 4-(1,3-th...

2-Aminothiazole Structure

2-Aminothiazole

2-(Trifluoromethyl)phenyl isocyanate Structure

2-(Trifluoromet...

~%

1-(1,3-thiazol-2-yl)-3-[2-(trifluoromethyl)phenyl]urea Structure

1-(1,3-thiazol-...

Acetamide,2-chloro-N-1,3,4-thiadiazol-2-yl- Structure

Acetamide,2-chl...

4-Toluenesulfonamide Structure

4-Toluenesulfonamide

~%

Benzenesulfonamide,4-methyl-N-[(2-thiazolylamino)carbonyl]- Structure

Benzenesulfonam...

4-Methylthiazol-2-amine Structure

4-Methylthiazol...

ethyl 4-isocyanatobenzoate Structure

ethyl 4-isocyan...

~%

Benzoic acid, 4-[[[(4-methyl-2-thiazolyl)amino]carbonyl]amino]-, ethyl ester Structure

Benzoic acid, 4...

Benzo[d]thiazol-2-amine Structure

Benzo[d]thiazol...

ethyl 4-isocyanatobenzoate Structure

ethyl 4-isocyan...

~%

ethyl 4-(benzothiazol-2-ylcarbamoylamino)benzoate Structure

ethyl 4-(benzot...

2-Amino-1,3,4-thiadiazole Structure

2-Amino-1,3,4-t...

Phenylisocyanate Structure

Phenylisocyanate

~%

Urea,N-phenyl-N'-1,3,4-thiadiazol-2-yl- Structure

Urea,N-phenyl-N...

Aminothiazoline Structure

Aminothiazoline

ethyl 4-isocyanatobenzoate Structure

ethyl 4-isocyan...

~%

Benzoic acid,4-[[[(4,5-dihydro-2-thiazolyl)amino]carbonyl]amino]-, ethyl ester Structure

Benzoic acid,4-...

2-Aminothiazole Structure

2-Aminothiazole

4-Cyanophenyl isocyanate Structure

4-Cyanophenyl i...

~%

Urea, N-(4-cyanophenyl)-N-2-thiazolyl- Structure

Urea, N-(4-cyan...