Journal of the American Chemical Society

SPIRO-PYRIMIDINES. II. CYCLOHEXANE-1, 5-SPIRO-PYRIMIDINES.

AW Dox, L Yoder

Index: Dox; Yoder Journal of the American Chemical Society, 1921 , vol. 43, p. 1368

Full Text: HTML

Citation Number: 7

Abstract

In the first paper'of this series a number of derivatives of cyclobutane-1, 5-spiro-pyrimidine were described. They may be regarded as variously substituted barbituric acids in which the 5-carbon atom enters into a 4-membered hydrocarbon ring. The method of preparation consists in condensing an a, a-dibromo-paraffin with ethyl malonate with formation of a cycloparaffin-1, l-dicarboxylic ester; the second ring is closed by condensation of the two ...