The reaction of D-glucono-&lactone with sulfanilamide to form N 4-~-gluconylsulfanilamide was carried out in hot dilute acetic acid solution. This procedure, however, was not applicable to the condensation of 2-keto-~-gluconic acid with sulfanilamide. The diisopropylidene-2-keto acid sulfanilamides were prepared by treating sulfanilamide in pyridine solution with the corresponding diisopropylidene 2-keto acid chlorides2 Acid ...
