Efficient selective synthesis of 2-substituted indoles from complex-base-promoted arynic cyclisations

C Kuehm-Caubère, I Rodriguez, B Pfeiffer…

Index: Kuehm-Caubere, Catherine; Rodriguez, Ivan; Pfeiffer, Bruno; Renard, Pierre; Caubere, Paul Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 19 p. 2857 - 2862

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Citation Number: 10

Abstract

2-Substituted indoles have been efficiently obtained by selective arynic cyclisation of halogenated aryl imines of methyl ketones in the presence of the complex-base NaNH2– ButONa and by PhCH2SH–AlCl3 opening of tetrahydrothiopyranoindoles also obtained from arynic cyclisation of imines.