An N-heterocyclic carbene (NHC) catalyzed intramolecular lactonization to prepare densely functionalized bicyclic γ-lactam-γ-lactone adducts from enals is reported. This method has been applied to the formal synthesis of salinosporamide A, a potent 20S proteasome inhibitor and anti-cancer therapeutic.
![Ethanone,2,2'-[(phenylmethyl)imino]bis[1-phenyl-, hydrobromide (1:1) Structure](https://image.chemsrc.com/caspic/433/31410-17-0.png)
