Medicinal Chemistry Research

Synthesis and in vitro antimicrobial activity of some newer quinazolinone–sulfonamide linked hybrid heterocyclic entities derived from glycine

SF Vanparia, TS Patel, RB Dixit, BC Dixit

Index: Vanparia, Satish F.; Patel, Tarosh S.; Dixit, Ritu B.; Dixit, Bharat C. Medicinal Chemistry Research, 2013 , vol. 22, # 11 p. 5184 - 5196

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Citation Number: 4

Abstract

Abstract A novel series of 4-(amino or acetamido)-N-{[3-(substituted aryl)-4-oxo-3, 4- dihydroquinazolin-2-yl]-methyl} benzenesulfonamide derivatives (1–19) were designed to assimilate 4-quinazolone and sulfonamide moieties in a single molecular framework. To derive entitled hybrid entities with structural diversity, an efficient multi-step synthetic approach initiated from glycine was developed, which involves milder conditions for ...