Friedel-Crafts alkylation of anisole and its comparison with toluene. Predominant ortho-para substitution under kinetic conditions and the effect of thermodynamic …

GA Olah, JA Olah, T Ohyama

Index: Olah, George A.; Olah, Judith A.; Ohyama, Toshiyuki Journal of the American Chemical Society, 1984 , vol. 106, # 18 p. 5284 - 5290

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Citation Number: 39

Abstract

Abstract: The AIC1, and BF,, as well as 65% HPF6, catalyzed Friedel-Crafts alkylation of anisole with alkyl halides and alcohols was investigated. The alkylation of anisole with lower catalyst concentrations under mild conditions shows predominant ortho/para directing effect generally with a ratio of-2: 1, with the amount of meta isomer uniformly less than 3%. With “swamping” catalyst conditions the amount of meta substitution in methylation and ...

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