Synthesis and Stereochemical Properties of “Extended” Biphenols Bridged by ortho??, meta??, and para??Phenylene Spacers

…, JC Chambron, E Espinosa, E Aubert

Index: Gruza, Mariusz M.; Chambron, Jean-Claude; Espinosa, Enrique; Aubert, Emmanuel European Journal of Organic Chemistry, 2009 , # 36 p. 6318 - 6327

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Citation Number: 2

Abstract

Abstract A series of isomeric biphenols based on para-(1), meta-(2), and ortho-(3) terphenyl backbones was synthesized. Suzuki cross-coupling methodology was employed for the construction of the terphenyl backbone of their methyl-protected precursors (respectively 8, 13, and 16). Using K 2 CO 3 as the base, the best reaction conditions involved DMF at 100 C as solvent. Anhydrous conditions greatly improved the yields of the sterically crowded ...