Heterocyclic ethers derived from 6, 11-dihydrodibenzo [b, e] thiepin-11-ols and 4, 9-dihydrothieno [2, 3-c]-2-benzothiepin-4-ol; A new series of potential …

Z Polívka, J Metyš, M Protiva

Index: Polivka, Zdenek; Metys, Jan; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 9 p. 2034 - 2049

Full Text: HTML

Citation Number: 14

Abstract

Abstract Reactions of 11-chloro-6, 11-dihydrodibenzo [b, e] thiepin and methanesulfonates of 6, 11-dihydrodibenzo [b, e] thiepin-11-ol (I), its 2-methyl derivative II and 4, 9- dihydrothieno [2, 3-c]-2-benzothiepin-4-ol (III) with 1-methylpiperidin-4-ol, 1- methylperhydroazepin-4-ol (XIX), and tropine gave the ethers VX. Their methanesulfonates were pharmacologically tested and showed antireserpine, anticataleptic, and ...