New nonnucleoside substrates for terminal deoxynucleotidyl transferase: synthesis and dependence of substrate properties on structure

AL Khandazhinskaya, MK Kukhanova…

Index: Khandazhinskaya; Kukhanova; Jasko Russian Journal of Bioorganic Chemistry, 2005 , vol. 31, # 4 p. 352 - 356

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Citation Number: 4

Abstract

Abstract N-(9-Fluorenylmethoxycarbonyl)-ω-aminoalkyl-, N-(9-fluorenylmethoxycarbonyl)-8- amino-3, 6-dioxaoctyl, and N-[(9-fluorenylmethoxycarbonyl)-6-aminohexanoyl]-2-aminoethyl triphosphates were synthesized. All of them were shown to be the substrates of the calf thymus terminal deoxynucleotidyl transferase. Their substrate properties depend on the length and structure of the linker between the 9-fluorenylmethoxycarbonyl and ...