Tetrahedron Letters

Sulfated tungstate: a green catalyst for Strecker reaction

SP Pathare, KG Akamanchi

Index: Pathare, Sagar P.; Akamanchi, Krishnacharya G. Tetrahedron Letters, 2012 , vol. 53, # 7 p. 871 - 875

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Citation Number: 23

Abstract

A straightforward, mild, efficient, and general method has been developed for the synthesis of α-aminonitriles via Strecker reaction starting from aldehydes or ketones, amines, and trimethylsilyl cyanide in the presence of sulfated tungstate as a heterogeneous mild solid acid catalyst at room temperature and solvent free condition. The developed method has been successfully applied for the synthesis of a wide range of α-aminonitriles with variable ...