Synthesis and antiinflammatory activity of acylated benzoxa-and benzodioxaheterocycles and their acyclic analogs

VK Daukshas, PG Gaidyalis, OY Pyatrauskas…

Index: Daukshas, V. K.; Gaidyalis, P. G.; Pyatrauskas, O. Yu.; Udrenaite, E. B.; Gasperavichene, G. A.; Raguotene, N. V. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 5 p. 341 - 345 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 5 p. 569 - 573

Full Text: HTML

Citation Number: 0

Abstract

Some benzoylated benzoxa-and benzodioxaheterocyc! es have been found to possess antiinflammatory activity [5]. With the aim, therefore, of investigating structure-activity relationships and of identifying novel antiinflammatory drugs, we have synthesized and tested benzoxa-and benzodioxaheterocycles and their acyclic analogs, containing an acy! substituent of the aliphatic series (Ib-f, i, IIc, i, IIIc, i, IVc, i, Vc, fj, VIc, i, VIii, VIIIi, IXc, f, i) or ...