[4-[[1-[(3-氟苯基)甲基]-1H-吲唑-5-基]氨基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氨基甲酸 (3S)-3-吗啉基甲基酯盐酸盐

更新时间：2025-08-20 20:36:17

[4-[[1-[(3-氟苯基)甲基]-1H-吲唑-5-基]氨基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氨基甲酸 (3S)-3-吗啉基甲基酯盐酸盐结构式	常用名	[4-[[1-[(3-氟苯基)甲基]-1H-吲唑-5-基]氨基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氨基甲酸 (3S)-3-吗啉基甲基酯盐酸盐	英文名	BMS-599626 (Hydrochloride)
	CAS号	873837-23-1	分子量	567.014
	密度	N/A	沸点	N/A
	分子式	C₂₇H₂₈ClFN₈O₃	熔点	N/A
	MSDS	N/A	闪点	N/A

用途

AC480 (BMS-599626)是 HER1和HER2选择性高效抑制剂,IC50分别为20 nM和30 nM,比针对VEGFR2,c-Kit,Lck,MET的抑制性强100倍以上。

中文名	BMS-599626盐酸盐
英文名	[(3S)-morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate,hydrochloride
英文别名	更多

描述	AC480 (BMS-599626)是 HER1和HER2选择性高效抑制剂,IC50分别为20 nM和30 nM,比针对VEGFR2,c-Kit,Lck,MET的抑制性强100倍以上。
相关类别	研究领域 >> 癌症
参考文献	[1]. Wong TW, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93. [2]. Torres MA, et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug;29(4):554-61.

描述

AC480 (BMS-599626)是 HER1和HER2选择性高效抑制剂,IC50分别为20 nM和30 nM,比针对VEGFR2,c-Kit,Lck,MET的抑制性强100倍以上。

相关类别

研究领域 >> 癌症

参考文献

[1]. Wong TW, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.

[2]. Torres MA, et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug;29(4):554-61.

分子式	C₂₇H₂₈ClFN₈O₃
分子量	567.014
精确质量	566.195679
PSA	126.35000
LogP	4.42160
储存条件	-20°C，保存于惰性气体中

(S)-tert-butyl ...

714971-12-7

~76%

[4-[[1-[(3-氟苯基)...

873837-23-1

文献：Gavai, Ashvinikumar V.; Fink, Brian E.; Fairfax, David J.; Martin, Gregory S.; Rossiter, Lana M.; Holst, Christian L.; Kim, Soong-Hoon; Leavitt, Kenneth J.; Mastalerz, Harold; Han, Wen-Ching; Norris, Derek; Goyal, Bindu; Swaminathan, Shankar; Patel, Bharat; Mathur, Arvind; Vyas, Dolatrai M.; Tokarski, John S.; Chiang, Yu; Oppenheimer, Simone; Hongjian, Zhang; Marathe, Punit; Fargnoli, Joseph; Lee, Francis Y.; Wong, Tai W.; Vite, Gregory D. Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6527 - 6530

上游产品 1
CAS号714971-12-7 (S)-tert-butyl ...
下游产品 0

Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, hydrochloride (1:1)

(3S)-3-Morpholinylmethyl (4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate hydrochloride (1:1)

cc-199

S1056_Selleck

BMS-599626 (Hydrochloride)