1-[1-(4-氯苯基)环丁基]-3-甲基丁胺盐酸盐

• 常用名: 1-[1-(4-氯苯基)环丁基]-3-甲基丁胺盐酸盐
• 英文名: BTS 54-505 hydrochloride
• CAS号: 84484-78-6
• 分子量: 288.26
• 密度: N/A
• 沸点: 337.9ºC at 760 mmHg
• 分子式: C₁₅H₂₃Cl₂N
• 熔点: 160 - 166°C (lit.)
• 闪点: 195.1ºC

用途

Didesmethylsibutramine (BTS 54-505) hydrochloride 是西布曲明 (Sibutramine) (抗抑郁和抗肥胖化合物)的伯胺代谢物。Didesmethylsibutramine 抑制 NMDA 诱发的活性。Didesmethylsibutramine 也是一种再摄取抑制剂。Didesmethylsibutramine 诱导产热。

1-[1-(4-氯苯基)环丁基]-3-甲基丁胺盐酸盐名称

• 中文名: 1-[1-(4-氯苯基)环丁基]-3-甲基丁胺盐酸盐
• 英文名: 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine,hydrochloride
• 中文别名: 氮位N-二去甲基盐酸西布曲明

1-[1-(4-氯苯基)环丁基]-3-甲基丁胺盐酸盐生物活性

• 描述: Didesmethylsibutramine (BTS 54-505) hydrochloride 是西布曲明 (Sibutramine) (抗抑郁和抗肥胖化合物)的伯胺代谢物。Didesmethylsibutramine 抑制 NMDA 诱发的活性。Didesmethylsibutramine 也是一种再摄取抑制剂。Didesmethylsibutramine 诱导产热。
• 相关类别:
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Liu YL, et al. Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine. Int J Obes Relat Metab Disord. 2002 Sep;26(9):1245-53.

  [2]. Scott G, et al. The effects of BTS 54,505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. Br J Pharmacol. 1994 Jan;111(1):97-102.

1-[1-(4-氯苯基)环丁基]-3-甲基丁胺盐酸盐物理化学性质

• 沸点: 337.9ºC at 760 mmHg
• 熔点: 160 - 166°C (lit.)
• 分子式: C₁₅H₂₃Cl₂N
• 分子量: 288.26
• 闪点: 195.1ºC
• 精确质量: 287.120758
• PSA: 26.02000
• LogP: 5.63740
• 外观性状: 白色至米白色固体
• 储存条件: Desiccate at RT

1-[1-(4-氯苯基)环丁基]-3-甲基丁胺盐酸盐MSDS

1-[1-(4-氯苯基)环丁基]-3-甲基丁胺盐酸盐MSDS英文版

1-[1-(4-氯苯基)环丁基]-3-甲基丁胺盐酸盐英文别名

• MFCD03411585
• Didesmethylsibutramine hydrochloride
• Bts 54 505
• Cyclobutanemethanamine, 1-(4-chlorophenyl)-α-(2-methylpropyl)-, hydrochloride (1:1)
• UNII:XJH8PK8XYH
• 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutan-1-amine hydrochloride (1:1)
• Cyclobutanemethanamine, 1-(4-chlorophenyl)-α-(2-methylpropyl)-, hydrochloride
• 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methyl-1-butanamine hydrochloride (1:1)
• 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride