2-[4-[[4-(3,4-Dichlorophenoxy)-1-piperidinyl]methyl]-1-piperidinyl]-benzoic acid

• 常用名: 2-[4-[[4-(3,4-Dichlorophenoxy)-1-piperidinyl]methyl]-1-piperidinyl]-benzoic acid
• 英文名: 2-[4-[[4-(3,4-Dichlorophenoxy)-1-piperidinyl]methyl]-1-piperidinyl]-benzoic acid
• CAS号: 796594-43-9
• 分子量: 463.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₈Cl₂N₂O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 2-[4-[[4-(3,4-Dichlorophenoxy)-1-piperidinyl]methyl]-1-piperidinyl]-benzoic acid

物理化学性质

• 分子式: C₂₄H₂₈Cl₂N₂O₃
• 分子量: 463.4
• InChIKey: UMSPPMMERAOIRT-UHFFFAOYSA-N
• SMILES: O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1

靶点实验

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实验名称：Binding affinity to histamine H1 receptor 来源：ChEMBL 靶标：Histamine H1 receptor External Id：CHEMBL2160725

实验名称：Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL2160723

实验名称：Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement a... 来源：ChEMBL 靶标：C-C chemokine receptor type 3 External Id：CHEMBL2160724

实验名称：ASTRAZENECA: Intrinsic clearance measured in human liver microsomes following incubat... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301370

实验名称：Oral bioavailability in rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2160729

实验名称：ASTRAZENECA: Second most basic pKa value (pKa B2) determined by absorption and potent... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301373

实验名称：Lipophilicity, log D of the compound at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL2160730

实验名称：ASTRAZENECA: Most acidic pKa value (pKa A1) determined by absorption and potentiometr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301375

实验名称：Half life in iv dosed rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2160728

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

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