Cannflavin A

• 常用名: Cannflavin A
• 英文名: Cannflavin A
• CAS号: 76735-57-4
• 分子量: 436.50
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₈O₆
• 熔点: N/A
• 闪点: N/A

Cannflavin A用途

从大麻中可以分离到核黄素A。核黄素A具有抗癌、神经保护和抗炎活性。核黄素A抑制Aβ1-42聚集。核黄素A还抑制犬尿氨酸-3-单加氧酶(KMO)。核黄素A通过胱天蛋白酶-3裂解激活细胞凋亡[1][2][3][4]。

Cannflavin A名称

• 英文名: Cannflavin A

Cannflavin A生物活性

• 描述: 从大麻中可以分离到核黄素A。核黄素A具有抗癌、神经保护和抗炎活性。核黄素A抑制Aβ1-42聚集。核黄素A还抑制犬尿氨酸-3-单加氧酶(KMO)。核黄素A通过胱天蛋白酶-3裂解激活细胞凋亡[1][2][3][4]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Rea KA, et al. Biosynthesis of cannflavins A and B from Cannabis sativa L. Phytochemistry. 2019 Aug;164:162-171.

  [2]. Eggers C, et al. Novel cannabis flavonoid, cannflavin A displays both a hormetic and neuroprotective profile against amyloid β-mediated neurotoxicity in PC12 cells: Comparison with geranylated flavonoids, mimulone and diplacone. Biochem Pharmacol. 2019 Nov;169:113609.

  [3]. Puopolo T, et al. Gram-Scale Preparation of Cannflavin A from Hemp (Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase. Biology (Basel). 2022 Sep 28;11(10):1416.

  [4]. Tomko AM, et al. Anti-cancer properties of cannflavin A and potential synergistic effects with gemcitabine, cisplatin, and cannabinoids in bladder cancer. J Cannabis Res. 2022 Jul 22;4(1):41.

Cannflavin A物理化学性质

• 分子式: C₂₆H₂₈O₆
• 分子量: 436.50
• InChIKey: MWGFICMOCSIQMV-LZYBPNLTSA-N
• SMILES: COc1cc(-c2cc(=O)c3c(O)c(CC=C(C)CCC=C(C)C)c(O)cc3o2)ccc1O